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Breast self-examination is associated with a lower risk of breast cancer incidence and mortality. To test for an association between breast self-examination (BSE) and the risk of breast cancer in women. We conducted a prospective, population-based study including 90 587 women aged 25-74 years enrolled in the Swedish Mammography Cohort. We used Poisson regression to estimate incidence rate ratios (IRRs) and hazard ratios (HRs) and Cox regression models to estimate hazard ratios. We excluded women with prevalent breast cancer at baseline (n = 2315) and women with self-reported prior breast cancer (n = 1234). We excluded women with bilateral breast cancer (n = 339), those with missing data for BSE at baseline (n = 626), and those with incomplete follow-up (n = 871). After exclusions, we included 91 170 women (40 942 controls and 50 228 cases) in the analysis. In the multivariable models, BSE was inversely associated with the risk of all breast cancers (IRR = 0.78, 95% confidence interval [CI] 0.74-0.83) and the risk of invasive breast cancer (HR = 0.84, 95% CI 0.77-0.91). Furthermore, BSE was associated with a decreased risk of mortality from breast cancer in the multivariable Cox model (HR = 0.80, 95% CI 0.74-0.87). When restricted to women who performed BSE regularly at baseline, this trend remained (IRR = 0.81, 95% CI 0.73-0.90; HR = 0.90, 95% CI 0.82-0.99; HR = 0.89, 95% CI 0.80-0.99, respectively). Our results indicate that BSE is associated with a decreased risk of incidence and mortality from breast cancer and a decreased risk of incident breast cancer.The REE-Mediated Cyanotoxin α-Hemolysin Is a Potent Cytotoxin and an Essential Pathogenicity Factor for Salmonella Gallinarum Infection. Salmonella enterica serovar Gallinarum is an important avian pathogen with a broad host range. Among its virulence factors, the pathogenicity island 2 (SPI2) encoded type III secretion system 2 (T3SS2) contributes to numerous aspects of infection, including the invasion of host cells and evasion of

 

 


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